Session IV: The Molecular Orchestra of Performance

We know physical activity has a host of health and performance benefits, and yet the mechanisms behind these relationships remain unclear. Researchers at the Wu Tsai Human Performance Alliance are working to measure the molecular changes that occur during physical activity to advance our understanding of its health benefits. 

Dr. Jonathan Long, a Stanford Agility Project Awardee, for example, found that blood levels of the molecule Lac-Phe rise 10-fold or more after vigorous exercise like HIIT, and that this heightened level of Lac-Phe acts in the mouse brain to suppress feeding.

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Other Presentations During This Session

  • Dr. Satchidananda (Satchin) Panda on the potential of time-restricted feeding to prevent and reverse metabolic diseases. Dr. Panda leads the Wu Tsai Human Performance Alliance at the Salk Institute.
  • Dr. Malene Lindholm on using a multi-omic atlas approach to elucidate the mechanisms behind adaptations to endurance training and optimal performance. She specifically explores mitochondrial changes during exercise. Dr. Lindholm is part of the Molecular Athlete moonshot efforts at Stanford.
  • Dr. Samuel R. Ward on understanding chronic muscle atrophy and cell death in rotator cuff injuries. Dr. Ward is the lead of the UC San Diego Innovation Hub, theTriton Center for Performance and Injury.






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